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December 8, 2025BloodOpen Access

Molecular distinctiveness of duodenal-type follicular lymphoma revealed by integrated multi-omic analysis

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Authors

SFSuguru FukuharaSMShinichi MakitaHMHiroyuki Mano

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Overview

Integrated multi-omic analysis reveals distinct molecular features and survival pathways in duodenal-type follicular lymphoma, indicating unique biology compared to other follicular lymphoma subtypes.

Key Points

  • This research aims to define the molecular characteristics of duodenal-type follicular lymphoma (DTFL) through comprehensive analysis.
  • Analyzed fresh-frozen endoscopic biopsy specimens from 23 patients with DTFL and 8 gastric MALT lymphoma controls.
  • Performed whole-exome sequencing and RNA sequencing to profile genetic mutations and expression.
  • Utilized differential gene expression and pathway enrichment analyses to identify unique molecular features.
  • Identified key mutations in CREBBP, BCL2, KMT2D, CARD11, HVCN1, and EEF1A1 in DTFL samples.
  • Found enrichment of pathways related to WNT signaling and chromatin remodeling in DTFL.
  • Distinct molecular profiles segregated DTFL from gastric MALT lymphoma and other follicular lymphoma types.

Cite This Study

Fukuhara et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e573https://doi.org/10.1182/blood-2025-3524
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic and Transcriptomic Profiles Identify Potential Therapeutic Targets of Concurrent Follicular and Diffuse Large B‐Cell Lymphoma and Transformed Follicular Lymphoma2026 · 1 citations
  2. 2Integrated single-cell and spatial analysis identifies T cell exhaustion and adhesion signatures in early follicular lymphoma transformation2025
  3. 3Beyond the Surface: Duodenal‐Type Follicular Lymphoma Diagnosed Despite Normal‐Appearing Duodenal Mucosa and Absence of Focal Duodenal FDG Uptake2026
  4. 4Intratumoral B cell diversity in follicular lymphoma revealed by single-cell paired transcriptome and BCR sequencing2025
  5. 5Identification of genetic subtypes in follicular lymphoma2024 · 13 citations