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December 8, 2025Blood

A single cell multiomic approach to dissect immunophenotypic plasticity in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) pediatric patients

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Authors

FLFranco Locatelli

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Overview

Single-cell analysis uncovers epigenetic regulation affecting immunophenotypic plasticity in pediatric acute lymphoblastic leukemia patients.

Key Points

  • This research aims to dissect the immunophenotypic plasticity in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
  • Utilized single-cell multiomic profiling on BCP-ALL samples at diagnosis and after 15 days of induction therapy
  • Applied multiparametric flow cytometry to assess immunophenotypic changes
  • Investigated the methylome and transcriptomic profiles to identify regulatory mechanisms
  • Identified significant differences in cell populations between mm-SWpos and mm-SWneg BCP-ALLs
  • Revealed a strong immature phenotype in mm-SWpos at diagnosis
  • Demonstrated distinct DNA methylation patterns in mm-SWpos BCP-ALLs, indicating divergent epigenetic landscapes

Cite This Study

Franco Locatelli (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5f2https://doi.org/10.1182/blood-2025-36
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