Gold-catalyzed cascade reaction performs 1,2-C,N-difunctionalizations in alkenyl-arylalkynes, indicating novel mechanistic insights.
This work reports gold-catalyzed novel 1,2-C,N-difunctionalizations of 2-alkenyl-1-arylalkynes with nitrones, along with the C═C double bond cleavage of substrates. Our mechanistic analysis suggests that gold directs an initial attack of N-hydroxyaniline on such enynes, followed by a cascade reaction with one nitrone molecule before the C═C double bond cleavage.
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Sadaphal et al. (2025) studied this question.
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