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December 11, 2025ACS Chemical Neuroscience

Decoding the Neuroprotective Intervention of Angiotensin Receptor Blockers: A Multimodal Approach Using In Silico Network Pharmacology, Molecular Modeling, and In Vivo Validation of Key Markers

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Authors

VKVarnita KarmakarAMAnkit MajieAGArya Ghosh

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Overview

Comparative analysis reveals angiotensin receptor blockers improve dementia outcomes, indicating network pharmacology aids neuroprotection understanding.

Key Points

  • The study investigates the neuroprotective effects of angiotensin receptor blockers in dementia models.
  • Utilized a network pharmacology approach to analyze interactions of ARBs with target proteins.
  • Conducted docking studies to evaluate binding affinities of ARBs with key proteins like AKT1 and PIK3CA.
  • Performed molecular dynamics simulations to confirm stability of azilsartan interactions.
  • Executed in vivo studies in a scopolamine-induced memory impaired model.
  • Identified 12 key target proteins related to dementia pathology.
  • Found strong binding affinities for azilsartan, olmesartan, and telmisartan.
  • Molecular dynamics confirmed favorable interactions of azilsartan with targets.
  • In vivo studies showed significant restoration of AKT1 and PIK3CA levels.

Cite This Study

Karmakar et al. (2025) studied this question.

synapsesocial.com/papers/69401b0d2d562116f28f728bhttps://doi.org/10.1021/acschemneuro.5c00769
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