New protocol transforms natural products and ketones into vinyl sulfones using aromatization and aryl acetylene, indicating potential in synthetic chemistry.
Ketones, as simple and readily available bulk chemicals, have long been the focus of synthetic chemistry. Herein, we report a new protocol for the radical deconstruction of unstrained ketones by in situ conversion of them into dihydroquinoline (DHQ) prearomatics and subsequent oxidative aromatization. By combination with subsequent radical cascade reactions of DABSO and aryl acetylene, this protocol can convert acyclic and cyclic ketones and even ketone-containing complex natural products into a series of valuable vinyl sulfones in a one-pot, two-step method.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: