What type of study is this?

This is a Human Clinical Trial study (also classified as: Pre-Registered Trial, RCT).

What question did this study set out to answer?

To compare combined aerobic–resistance training and high-intensity interval training on outcomes in type 2 diabetes.

December 10, 2025PLoS ONEOpen Access

Comparative effects of combined aerobic and resistance training versus high-intensity interval training on insulin resistance, glycaemic control, body composition and quality of life in type 2 diabetes: A 12-week randomised controlled trial

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Authors

SASampath Kumar AmaravadiUniversity of Birmingham AFArthur de Sã¡ Ferreira PVPatrícia dos Santos VigárioUniversity Center Augusto Motta

Discussion

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Implication

Randomised controlled trial shows HIIT benefits fasting glucose and muscle mass in type 2 diabetes, implying both A+R and HIIT can improve quality of life.

Key Points

To compare combined aerobic–resistance training and high-intensity interval training on outcomes in type 2 diabetes.
Single-centre, randomised controlled trial with 90 participants aged 30-65 with type 2 diabetes.
Participants were allocated to A + R, HIIT, or control groups for 12 weeks.
Interventions included moderate-intensity aerobic plus resistance exercises or structured HIIT, delivered 3–5 times weekly.
HIIT reduced fasting glucose by 29.1 mg/dL and A+R by 20.6 mg/dL compared to control.
Both interventions showed significant reductions in HbA1c and fasting insulin levels versus control.
Functional capacity improved significantly with HIIT and A+R, as measured by the 6-minute walk distance.

Cite This Study

Amaravadi et al. (2025) studied this question.

synapsesocial.com/papers/69401d542d562116f28f8a1b https://doi.org/10.1371/journal.pone.0336898

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Implication

Randomised controlled trial shows HIIT benefits fasting glucose and muscle mass in type 2 diabetes, implying both A+R and HIIT can improve quality of life.

Comparative effects of combined aerobic and resistance training versus high-intensity interval training on insulin resistance, glycaemic control, body composition and quality of life in type 2 diabetes: A 12-week randomised controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparative effects of combined aerobic and resistance training versus high-intensity interval training on insulin resistance, glycaemic control, body composition and quality of life in type 2 diabetes: A 12-week randomised controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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