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December 9, 2025PLoS PathogensOpen Access

Antiviral and immune modulatory activities of STING agonists in a mouse model of persistent hepatitis B virus infection

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Authors

YWYa WangSWShuo WuXLXing-qiong Li

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Overview

Treatment with STING agonists improves immune responses and reduces HBV replication in mice, suggesting potential for chronic hepatitis B therapy.

Key Points

  • This research aims to explore the antiviral and immune modulatory effects of STING agonists in a mouse model of chronic hepatitis B virus infection.
  • Utilized STING knockout and human STING knock-in mouse models
  • Administered STING agonist diABZI at optimized doses
  • Conducted virological and hepatic bulk and single-cell RNA-seq analyses
  • STING agonist treatment activated innate immune responses in the spleen and liver
  • Suppressed HBV DNA replication in AAV-HBV transduced mice
  • Detected antibodies against HBV surface antigen (HBsAg) in 1/4 mice after 5 weeks of treatment

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69401efa2d562116f28f9a69https://doi.org/10.1371/journal.ppat.1013709
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antiviral and immune modulatory activities of STING agonists in a mouse model of persistent hepatitis B virus infection2025
  2. 2A novel LNP/mRNA-based STING immunotherapy approach for chronic HBV infection 23349472026
  3. 3The lignan compound matairesinol monoglucoside induces type I interferon production in HBV infection immunity by regulating STING signaling2025 · 1 citations
  4. 4Stimulator of Interferon Gene Agonists Induce an Innate Antiviral Response against Influenza Viruses2024 · 1 citations
  5. 5Activation of the cGAS-STING pathway by viral dsDNA leading to M1 polarization of macrophages mediates antiviral activity against hepatitis B virus2024 · 19 citations