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January 1, 2025RSC Medicinal ChemistryOpen Access

The lignan compound matairesinol monoglucoside induces type I interferon production in HBV infection immunity by regulating STING signaling

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Authors

ZSZhijun SuDZDawu ZengJLJiangfu Liu

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Overview

Preclinical study reveals matairesinol monoglucoside reduces hepatitis B viral markers in murine liver cells, indicating its therapeutic promise via STING activation.

Key Points

  • To assess the therapeutic potential and mechanistic action of the lignan compound matairesinol monoglucoside against hepatitis B virus infection.
  • Administered matairesinol monoglucoside (MMG) pre-treatment to mice prior to adeno-associated virus-mediated hepatitis B virus (AAV-HBV) infection.
  • Assessed viral antigen production, viral replication, and type I interferon responses in primary hepatocytes and Kupffer cells from wild-type and STING-knockout models.
  • MMG treatment significantly decreased HBV DNA, HBsAg, and HBeAg expression in both primary hepatocytes and Kupffer cells.
  • MMG enhanced IFN-α and IFN-β production by activating the STING-TBK1-IRF3 signaling pathway, an immunostimulatory effect abolished upon STING knockout.

Cite This Study

Su et al. (2025) studied this question.

synapsesocial.com/papers/6a7cc0de1c02bd024a6ee9f6https://doi.org/10.1039/d5md00468c
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