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December 8, 2025Scientific ReportsOpen Access

Safety assessment and in vitro cytotoxicity profiling of fruiting bodies from Lentinula edodes (shiitake) strains in HeLa and MCF-7 cell lines

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Authors

ASAjay SinghSASudheer Kumar Annepu

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Overview

In vitro cytotoxicity assessment shows shiitake strain DMRO-356 has anti-proliferative effects, suggesting potential for dietary supplements.

Key Points

  • Cytotoxicity profiling indicated promising anti-proliferative effects of DMRO-356 in MCF-7 cells, pointing to its therapeutic potential.
  • Quantified β-glucan content confirmed the nutraceutical properties of the strains L. edodes in dietary supplements.
  • In vitro analysis included MTT and LDH assays on HeLa and MCF-7 cell lines, ensuring comprehensive safety assessment.
  • Bioactive properties support the potential role of shiitake mushrooms in cancer prevention and immune support strategies.

Cite This Study

Singh et al. (2025) studied this question.

synapsesocial.com/papers/694020e22d562116f28faa7chttps://doi.org/10.1038/s41598-025-27701-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety assessment and in vitro cytotoxicity profiling of fruiting bodies from Lentinula edodes (shiitake) strains in HeLa and MCF-7 cell lines2025
  2. 2Holistic Evaluation of Shiitake mushrooms (<i>Lentinula edodes</i>): Unraveling Its Medicinal and Therapeutic Potentials2025
  3. 3Bioactive metabolites from edible fungi: evaluation of antioxidant potential and cytotoxicity on human cell lines2026 · 2 citations
  4. 4Partially Purified Polysaccharides from Lentinus edodes (Mushroom) Scavenge Free Radicals and Induce Apoptosis in MCF-7 Cancer Cells by Regulating Apoptotic Genes2024 · 1 citations
  5. 5Cosmeceutical and Dermatological Potential of Shiitake Mushroom ( <i>Lentinula edodes</i> ) Extract2026