Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Scientific ReportsOpen Access

Safety assessment and in vitro cytotoxicity profiling of fruiting bodies from Lentinula edodes (shiitake) strains in HeLa and MCF-7 cell lines

View Full Paper
Ask AI
Bookmark
Share

Authors

SMSujata MakkarKNKiran NehraASAjay Singh

Discussion

Loading...

Member takes

Overview

In vitro analysis reveals anti-proliferative effects of shiitake strains, indicating their potential as therapeutic agents for cancer prevention.

Key Points

  • DMRO-356 showed greater anti-proliferative effects compared to DMRO-34 in MCF-7 cell line.
  • β-glucan content quantified using Megazyme assay in both strains of L. edodes.
  • Safety evaluation showed no observable adverse effects at a limit dose in rats over a 28-day period.
  • Findings support the use of L. edodes in dietary supplements and functional foods for cancer prevention.

Cite This Study

Makkar et al. (2025) studied this question.

synapsesocial.com/papers/694020e82d562116f28fac06https://doi.org/10.1038/s41598-025-27701-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety assessment and in vitro cytotoxicity profiling of fruiting bodies from Lentinula edodes (shiitake) strains in HeLa and MCF-7 cell lines2025
  2. 2Holistic Evaluation of Shiitake mushrooms (<i>Lentinula edodes</i>): Unraveling Its Medicinal and Therapeutic Potentials2025
  3. 3Bioactive metabolites from edible fungi: evaluation of antioxidant potential and cytotoxicity on human cell lines2026 · 2 citations
  4. 4Partially Purified Polysaccharides from Lentinus edodes (Mushroom) Scavenge Free Radicals and Induce Apoptosis in MCF-7 Cancer Cells by Regulating Apoptotic Genes2024 · 1 citations
  5. 5Cosmeceutical and Dermatological Potential of Shiitake Mushroom ( <i>Lentinula edodes</i> ) Extract2026