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December 8, 2025Archives of ToxicologyOpen Access

Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)

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Qualitative and quantitative analysis identifies cardiotoxicity and mutagenicity risks of phencyclidine analogs, suggesting need for risk assessment.

Moderate acute toxicity observed in phencyclidine analogs indicates substantial health risks, particularly for intravenous use.
Cardiotoxicity signals including hERG inhibition were significant, highlighting potential QT-prolongation risks.
Genotoxicity predictions remained consistently negative, indicating phencyclidine analogs are unlikely to be mutagenic.
Findings underscore the need for informed clinical management and forensic interpretation regarding phencyclidine analogues.

Noga et al. (2025) studied this question.

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Qualitative and quantitative analysis identifies cardiotoxicity and mutagenicity risks of phencyclidine analogs, suggesting need for risk assessment.