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December 8, 2025Archives of ToxicologyOpen Access

Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)

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Authors

MNMaciej Noga KJKamil Jurowski MNMaciej Noga

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Implication

Quantitative analysis of toxicity and cardiotoxicity in phencyclidine analogues, suggesting risks for clinical management and forensic interpretation.

Key Points

Moderate acute toxicity observed in phencyclidine analogues with LD50 values ranging 200-630 mg/kg.
Predictive models indicated significant cardiotoxicity signals, highlighting hERG inhibition risks.
Analysis utilized integrated in silico models to assess multiple toxicity domains for PCP analogues.
Findings support risk assessment and potential implications for clinical management of new psychoactive substances.

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Noga et al. (2025) studied this question.

synapsesocial.com/papers/694020e82d562116f28fac01 https://doi.org/10.1007/s00204-025-04242-6

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Implication

Quantitative analysis of toxicity and cardiotoxicity in phencyclidine analogues, suggesting risks for clinical management and forensic interpretation.

Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)

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Key Points

Cite This Study

Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)

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