Halogen-bond-based approach demonstrates efficient synthesis of perfluoroalkylated compounds under mild conditions, using electron donor.
A halogen-bond-based electron donor-acceptor (EDA) complex-promoted perfluoroalkylative cyclization of N-phenylmethacrylohydrazides was developed. In this reaction, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) functions as an electron donor and interacts with perfluoroiodocarbon to form the EDA complex, which produces a perfluoroakyl radical after irradiation by blue LEDs. A series of perfluoroalkylated pyrazol-5-ones were obtained in moderate to good yields under mild conditions without the requirement of any external photocatalyst.
No takes yet. Share an insight, caveat, or question.
Yu et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: