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December 6, 2025World Journal of PediatricsOpen Access

Small-molecule therapies for pediatric inflammatory bowel disease: toward precision medicine

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Authors

YCYing ChenYWYang WangJGJing Guo

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Overview

Review highlights efficacy of Janus kinase and sphingosine-1-phosphate modulators in pediatric IBD, suggesting a need for targeted clinical trials.

Key Points

  • Small-molecule therapies demonstrate promise in managing pediatric inflammatory bowel disease, aiding growth and development.
  • Evidence from clinical trials supports the effectiveness of Janus kinase inhibitors and sphingosine-1-phosphate modulators.
  • Review incorporates translational research and physiologically based pharmacokinetic modeling to inform treatment approaches.
  • Identifying biomarkers through integrated multiomics is crucial for optimizing safety and efficacy in pediatric populations.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/694020fd2d562116f28fb4ffhttps://doi.org/10.1007/s12519-025-01001-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in the Management of Pediatric Inflammatory Bowel Disease: From Biologics to Small Molecules2026 · 3 citations
  2. 2Advanced therapies in management of pediatric inflammatory bowel disease2026
  3. 3Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries2026
  4. 4Benefit-risk balance of advanced therapies in pediatric inflammatory bowel disease: evidence and gaps versus adults2026
  5. 5Inflammatory bowel disease in paediatrics: Navigating the old challenges and emerging frontiers2025 · 3 citations