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June 28, 2026Current Opinion in Pediatrics

Advanced therapies in management of pediatric inflammatory bowel disease

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Authors

JWJustin WilliamsBGBhaskar Gurram

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Overview

Review highlights advanced therapies and dual targeted therapy for improved outcomes in pediatric inflammatory bowel disease.

Key Points

  • This review aims to update management strategies for pediatric inflammatory bowel disease (PIBD) using advanced therapies.
  • Reviewed emerging therapies including vedolizumab, ustekinumab, and novel anti-IL-23p19 agents.
  • Analyzed data from pediatric clinical trials and real-world studies.
  • Discussed the implementation of dual targeted therapy for patients not achieving remission.
  • Vedolizumab and ustekinumab show promise as second-line therapies for PIBD.
  • Novel anti-IL-23p19 agents and oral Janus kinase inhibitors demonstrate positive results for refractory cases.
  • Proactive therapeutic drug monitoring enhances clinical remission rates and durability of treatment.

Cite This Study

Williams et al. (2026) studied this question.

synapsesocial.com/papers/6a40bb1461bb0a67205c6b02https://doi.org/10.1097/mop.0000000000001592
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in the Management of Pediatric Inflammatory Bowel Disease: From Biologics to Small Molecules2026 · 3 citations
  2. 2Small-molecule therapies for pediatric inflammatory bowel disease: toward precision medicine2025
  3. 3Benefit-risk balance of advanced therapies in pediatric inflammatory bowel disease: evidence and gaps versus adults2026
  4. 4Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries2026
  5. 5Refractory chronic inflammatory bowel disease in childhood and adolescence2026