What question did this study set out to answer?

To summarize the landscape of investigational and approved therapeutic agents evaluated in clinical trials for paediatric inflammatory bowel disease.

August 15, 2026Pediatric DrugsOpen Access

Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries

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To summarize the landscape of investigational and approved therapeutic agents evaluated in clinical trials for paediatric inflammatory bowel disease.
Conducted a cross-sectional review of interventional clinical trials registered on ClinicalTrials.gov and ClinicalTrialsRegister.eu involving paediatric patients (aged <18 years) through July 2, 2026.
Identified 123 completed trials (77 randomized controlled trials, 46 non-randomized) and 90 active trials (55 randomized controlled trials, 35 non-randomized).
Completed trials predominantly enrolled mixed adult and paediatric cohorts (71%), whereas nearly half of active trials exclusively enrolled paediatric participants (predominantly aged 2–17 years).
Biologics were evaluated in 81 trials (39 approved agents, 42 investigational agents), while small molecule therapies were assessed in 9 completed and 11 active trials.

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Implication

Cross-sectional review reveals an expanding pipeline of biologic and small molecule trials for paediatric inflammatory bowel disease, highlighting ongoing shifts toward paediatric-only studies.

Cite This Study

Gupte et al. (2026) studied this question.

synapsesocial.com/papers/6a8019f175c2e31742c8630f https://doi.org/10.1007/s40272-026-00766-1

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Implication

Cross-sectional review reveals an expanding pipeline of biologic and small molecule trials for paediatric inflammatory bowel disease, highlighting ongoing shifts toward paediatric-only studies.

Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries

Key Points

Discussion

Implication

Cite This Study

Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries

Key Points

Discussion

Implication

Cite This Study

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