Analysis shows altered effective connectivity relates to cognitive dysfunction in type 2 diabetes, suggesting new neural pathways to explore.
Our analysis of dynamic effective connectivity reveals that T2DM patients, particularly those with microvascular complications, undergo a state-dependent reconfiguration from compensatory high connectivity to inefficient low-connectivity states. The increased time spent in these inefficient states was associated with poorer glycemic control. Thus, this work provides a novel dynamic and directional framework for understanding the neural mechanisms of cognitive dysfunction in T2DM.
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Wang et al. (2025) studied this question.
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