Key result
Type 1 diabetic patients exhibited poorer cognitive performance than healthy controls regardless of microvascular complications, whereas functional connectivity was lowest in patients with retinopathy and increased in those without complications.
Why the study?
Does type 1 diabetes with or without microvascular complications affect functional brain connectivity and cognitive functioning compared to healthy controls?
Population
Patients with long-standing type 1 diabetes with and without proliferative retinopathy, and healthy control…
Comparison
Type 1 diabetes with and without microvascular… vs Healthy control subjects
Design
Cross-sectional
Authors
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Cognitive monitoring may be warranted in type 1 diabetes irrespective of complications; leaves open connectivity's mechanistic role.
Cross-Sectional (n=70)
Yes
Does type 1 diabetes with or without microvascular complications affect functional brain connectivity and cognitive functioning compared to healthy controls?
Type 1 diabetes is associated with poorer cognitive performance and altered functional brain connectivity, with connectivity changes varying based on the presence of microvascular complications.
Duinkerken et al. (2009) conducted a cross-sectional in Type 1 Diabetes (n=70). Type 1 diabetes with and without microvascular complications vs. Healthy control subjects was evaluated on Functional brain connectivity (synchronization likelihood) and neurocognitive functioning. Type 1 diabetic patients exhibited poorer cognitive performance than healthy controls regardless of microvascular complications, whereas functional connectivity was lowest in patients with retinopathy and increased in those without complications.
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