The synthesis reported constructs a tetracyclic skeleton for corynanthe alkaloids, suggesting efficient pathways using Wittig olefination and ketohydroxylation.
An efficient synthesis of a tetracyclic skeleton common to many corynanthe alkaloids was accomplished in 10 linear steps starting from a known tetrahydro β‐carboline intermediate. The tetracyclic α‐hydroxy keto functionalized advanced precursor of (±)‐mitralactonine was realized using Wittig olefination, ketohydroxylation of a trisubstituted alkene, and a tandem amine unmasking‐intramolecular nucleophilic displacement reaction for C–N bond formation of C/D‐rings.
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Dumare et al. (2025) studied this question.
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