Total Synthesis of Corynanthe Alkaloids: Corynantheol, Isocorynantheol, and Dihydrocorynantheol

Here, we present a new synthetic approach to an advanced intermediate of the Corynanthe alkaloids, employing the Ireland‐Claisen rearrangement (ICR) and the Pictet‐Spengler reaction (PSR) as key transformations. Furthermore, as a representative application of this strategy, we accomplished the racemic total synthesis of corynanthe‐related alkaloids, including corynantheol, isocorynantheol, dihydrocorynantheol, 15‐ epi ‐corynantheol, and 3‐ epi ‐corynantheidol. This work underscores the versatility and synthetic utility of our approach within the broader context of the corynanthe alkaloid class.