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December 14, 2025The Journal of Pathology Clinical ResearchOpen Access

Systemic and local decorin levels mirror the clinical course of pancreatic cancer

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Authors

MSMaja SvenssonSLSophie LehnHJHedda Jacobsen

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Overview

Observational study shows chemotherapy alters decorin dynamics in pancreatic cancer, indicating its prognostic potential.

Key Points

  • To investigate the clinical significance of decorin levels in pancreatic cancer patients during chemotherapy.
  • Measured soluble decorin levels using proximity extension assay in 124 patients
  • Applied multiplexed immunofluorescence to examine decorin expression in tumour tissue
  • Compared serum decorin levels in adjuvant and palliative chemotherapy patients.
  • Increased serum decorin levels observed after starting chemotherapy in palliative patients
  • Higher changes in decorin levels correlated with worse prognosis in both treatment types
  • Expression of decorin varied in tumour, immune, and stroma cells, particularly in B cells, linked to shorter survival.

Cite This Study

Svensson et al. (2025) studied this question.

synapsesocial.com/papers/6941aaa70f5af7fd17df4b87https://doi.org/10.1002/2056-4538.70066
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High MMP14 and low decorin expression correlate with disease progression and metastasis in Brazilian prostate cancer patients2026
  2. 2Unraveling the significance of decorin in endometriosis development through single cell sequencing and experimental approaches2026
  3. 3Decorin (DCN) Downregulation Activates Breast Stromal Fibroblasts and Promotes Their Pro-Carcinogenic Effects through the IL-6/STAT3/AUF1 Signaling2024 · 9 citations
  4. 4Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis2024 · 2 citations
  5. 5Recombinant Human Decorin Normalizes the Active Features of Breast Cancer-Associated Fibroblasts2026