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June 27, 2026Journal of Molecular HistologyOpen Access

High MMP14 and low decorin expression correlate with disease progression and metastasis in Brazilian prostate cancer patients

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Authors

AFAmanda L. FrancelinoFTFernando TerziotiGVGlauco A. F. Vitiello

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Overview

Randomized trial evaluates MMP14 and decorin correlation with metastasis in prostate cancer, suggesting prognostic significance.

Key Points

  • This research aims to explore the correlation between MMP14 and decorin expression and disease progression in prostate cancer.
  • Examined 92 prostate cancer tissue samples through immunohistochemical analysis.
  • Assessed expression levels of MMP14 and decorin in malignant tissue, adjacent non-tumor tissue, and peritumoral stroma.
  • Conducted multivariate analysis to evaluate the predictive value of MMP14 for metastasis.
  • High MMP14 expression was found in 60% of metastatic cases, significantly linked to metastasis (p=0.012).
  • Low decorin expression was noted in 63% of metastatic cases and correlated with ISUP grades 4–5 (p=0.047).
  • MMP14 expression serves as an independent predictor of metastasis (p=0.01).

Cite This Study

Francelino et al. (2026) studied this question.

synapsesocial.com/papers/6a3f69caaea7db3c195407dchttps://doi.org/10.1007/s10735-026-10869-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systemic and local decorin levels mirror the clinical course of pancreatic cancer2025
  2. 2Potential Prognostic and Metastatic Implications of MACC1 and MMP8 in Colorectal Cancer2026
  3. 3The multifunctional role of the immunohistochemical expression of MMP‐7 in invasive breast cancer2005 · 31 citations
  4. 4Unraveling the significance of decorin in endometriosis development through single cell sequencing and experimental approaches2026
  5. 5High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer2019 · 18 citations