Investigating the Effect of Synbiotic and SperiGen Supplementations on Spermatogram in Idiopathic Oligoasthenoteratozoospermia: A Double‐Blinded Randomized Clinical Trial

Background Male infertility is influenced by a variety of etiologies, including quantitative and qualitative impairments in spermatogenesis. Antioxidants scavenge reactive oxygen species (ROS), which reduce sperm motility, cause damage to DNA, and lead to subsequent apoptosis in sperm cells. This trial aimed to evaluate the effect of oral Synbiotic and a multivitamin‐mineral supplement for men helping to improve male fertility (SperiGen), as an antioxidant agent, on the spermatogram in idiopathic Oligoasthenoteratozoospermia (iOAT). Materials and Methods This double‐blind randomized clinical trial was conducted on infertile males with iOAT. Totally, 73 patients with iOAT were blindly randomized into two groups; one group received SperiGen as an antioxidant agent in addition to placebo. In the next group, in addition to SperiGen, the patients received 500 mg Synbiotic (FamiLact) on a daily basis. They continued their treatments for 3 months. Semen parameters were measured before and after the intervention. Results Supplementations with a combination of Synbiotic and SperiGen compared with SperiGen and placebo significantly increased the average change of sperm progressive motility ( p = 0.001), DNA fragmentation ( p = 0.001), and diminished the levels of non‐motile sperm ( p = 0.018). Eventually, within‐group analysis indicated that all parameters were significantly improved in both groups, except for non‐progressive motility in the SperiGen and placebo group. Conclusion The combination of Synbiotic and SperiGen (an antioxidant supplement) appears to be much more effective than using an antioxidant alone in improving the DNA fragmentation, concentration, and progressive motility of sperm. Trial Registration: IRCT20190810044500N6, 2020‐09‐05. https://irct.behdasht.gov.ir/trial/46773 . https://trial.medpath.com/clinical‐trial/7ad7a7af5cba37f3/evaluating‐symbiotic‐therapy‐male‐infertility