The Relationship between Obesity, Intraoperative Blood Loss, NLR, and CRP with Perioperative Complications in Colorectal Cancer Surgery

Aim: This study examines the relationship between obesity, intraoperative blood loss, and systemicinflammatory responses (NLR and CRP) concerning perioperative complications in colorectal cancersurgery. Methods: A retrospective analytical observational study was conducted on 96 patients whounderwent colorectal cancer surgery from January 1 to August 31, 2023. The analysis included obesityhistory, intraoperative blood loss, NLR, and CRP levels, using descriptive statistics, Chi-Square testsfor Odds Ratios (OR), and logistic regression for adjusted odds ratios. Results: The study found a38.5% complication rate in patients with BMI ≥25 kg/m² (OR=35) and a 29.5% rate in those with CRP>150 mg/L (OR=7). Patients with NLR >3 had a 21.1% complication rate (OR=1.3), while those withintraoperative blood loss >800 mL faced an 83.3% complication rate (OR=36). Logistic regressionindicated that obesity and CRP are independently associated with major complications. Conclusion:Obesity, intraoperative blood loss, NLR, and CRP collectively influence major perioperativecomplications, with obesity and CRP being the most significant independent factors in colorectal cancersurgery.