July 15, 1983Science
Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor
Key Points
- The aim is to explore the genetic relationship between the simian sarcoma virus onc gene v-sis and platelet-derived growth factor genes.
- Analysis of sequence similarity between v-sis onc gene and platelet-derived growth factor genes.
- Demonstration of protein expression characteristics akin to cellular factors.
- Identified extensive sequence similarity between the v-sis onc gene and human platelet-derived growth factor.
- Proposed that v-sis may transform cells by expressing proteins similar to those involved in normal cell growth.
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Discussion
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Implication
Demonstrates the similarity between the v-sis onc gene and platelet-derived growth factor, indicating shared origins.
Cite This Study
Doolittle et al. (1983) studied this question.