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This research aims to identify and evaluate novel phenylpropanoid-homoisoflavonoid derivatives from Hippophae rhamnoides and their pharmacological potential.

January 6, 2026

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Phenylpropanoid-homoisoflavonoid derivatives from the fruits of Hippophae rhamnoides L. and their hepatoprotective and hypolipidemic activities

QMQinge MaWuhan Polytechnic University YSYan-Li ShiWuhan Polytechnic University QLQi LiWuhan Polytechnic University

Key Points

This research aims to identify and evaluate novel phenylpropanoid-homoisoflavonoid derivatives from Hippophae rhamnoides and their pharmacological potential.
Isolation of twelve new and eleven phenylpropanoid-homoisoflavonoid derivatives from Hippophae rhamnoides fruits.
Assessment of hepatoprotective and hypolipidemic activities of isolated compounds.
New phenylpropanoid-homoisoflavonoid derivatives were identified and characterized.
The derivatives exhibited significant hepatoprotective and hypolipidemic effects.

Abstract

Twelve new phenylpropanoid-homoisoflavonoid derivatives (1-12), including (9→1'')-rutinosyl-12-methyl-6,7-furan-phenylpropanoid-homoisoflavonoids(1-3), (9→1'')-(3''-O-(3''''-methoxy-4''''-cinnamic acid))-(6''→1''')-diglucosylphenylpropanoid-homoisoflavonoids (4-6), (9→1'')-glucosyl-phenylpropanoidhomoisoflavonoids (7-9), 10-methylol-9-rutinosyl-(2''→1'''')-glucosyl phenylpropanoid-homoisoflavonoids (10-12), and eleven phenylpropanoidhomoisoflavonoid derivatives (13-23) were isolated from the fruits of Hippophae rhamnoides L. for...

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Ma et al. (Thu,) studied this question.

synapsesocial.com/papers/695d85653483e917927a4e71 https://doi.org/https://doi.org/10.1039/d5fo04099j

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