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January 29, 2013Journal of the American Society of Nephrology

Kidney Disease and Increased Mortality Risk in Type 2 Diabetes

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Authors

MAMaryam AfkarianUniversity of California, DavisMSMichael C. SachsUniversity of CopenhagenBKBryan KestenbaumUniversidade Federal de Minas Gerais

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Implication

Randomized trial examines mortality impact of kidney disease in type 2 diabetes, highlighting significant risk factors.

Key Points

  • This study aims to understand the contribution of kidney disease to mortality risk among individuals with type 2 diabetes.
  • Analyzed 10-year cumulative mortality data from 15,046 participants in NHANES III linked with the National Death Index.
  • Defined kidney disease using urinary albumin/creatinine ratio and estimated GFR metrics.
  • Adjusted mortality rates for demographics, smoking, blood pressure, and cholesterol levels.
  • 10-year cumulative mortality was 31.1% (95% CI, 24.7%-37.5%) in individuals with both diabetes and kidney disease.
  • Absolute risk difference between those with diabetes and kidney disease and the reference group was 23.4% (95% CI, 17.0%-29.9%).
  • Individuals with diabetes but no kidney disease had a mortality rate of 11.5% (95% CI, 7.9%-15.2%).

Cite This Study

Afkarian et al. (2013) studied this question.

synapsesocial.com/papers/695eafacd8a79a4631ef501bhttps://doi.org/10.1681/asn.2012070718
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