Key result
Myocardial metabolic shifts involving LCFAs, SCFAs, and KBs impact HFpEF progression through altered energy and signaling.
Why the study?
An in-depth molecular understanding of the biological functions of energy substrates and their signalling roles is needed to develop novel therapeutic approaches for HFpEF.
Design
Review
Authors
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Dual fuel-signaling roles of LCFAs, SCFAs, and KBs in HFpEF support metabolic targeting; leaves open efficacy in prospective trials.
Key points are not available for this paper at this time.
Capone et al. (2022) studied this question. Changes in myocardial energy metabolism, particularly involving LCFAs, SCFAs, and KBs, significantly impact both energy provision and signaling in HFpEF progression.
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