What does this research mean for the field?

TAG72 levels are significantly higher in patients with non-vein-dependent atrial fibrillation compared to those with vein-dependent atrial fibrillation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to identify a new predictor for recurrence of atrial fibrillation following catheter ablation.

January 10, 2026Journal of Cardiovascular Development and Disease0 citationsOpen Access

Atrial Fibrillation Recurrence After Catheter Ablation Is Associated with TAG72 Protein

KDKarapet V. DavtyanNational Research Center for Preventive Medicine AAAishat A. AbdullaevaNational Research Center for Preventive Medicine NGN. G. GumanovaNational Research Center for Preventive Medicine

Key Result

TAG72 levels were significantly higher in patients with non-vein-dependent atrial fibrillation (128.9 vs. 84.3, p < 0.001) compared to vein-dependent atrial fibrillation.

Key Points

This research aims to identify a new predictor for recurrence of atrial fibrillation following catheter ablation.
Enrolled patients with atrial fibrillation for prospective study.
Conducted a one-year follow-up and divided patients into two groups based on outcomes.
Used protein microarrays for initial proteomic profiling of serum.
Confirmed candidate proteins through enzyme-linked immunosorbent assay (ELISA).
TAG72 levels significantly differed between groups, with the non-vein-dependent group showing higher levels (128.9 vs. 84.3, p < 0.001).
First evidence of TAG72 involvement in the development of atrial fibrillation.

Structured PICO

Are elevated pre-procedural serum TAG72 protein levels associated with 'non-vein-dependent' atrial fibrillation recurrence after catheter ablation?

Population

Patients with atrial fibrillation undergoing catheter ablation

Intervention

Measurement of pre-procedural serum TAG72 protein levels

Comparator

Group 1 ('vein-dependent' AF with successful outcome after 1-2 procedures) vs Group 2 ('non-vein-dependent' AF with confirmed complete pulmonary vein isolation or identified non-vein-dependent substrate)

Outcome

Atrial fibrillation recurrence or identification of 'non-vein-dependent' AF substrate at one-year follow-upsurrogate

Elevated pre-procedural serum TAG72 protein levels may serve as a novel biomarker for predicting 'non-vein-dependent' atrial fibrillation recurrence after catheter ablation.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Despite the efficacy of catheter ablation in preventing recurrences of atrial fibrillation (AF), the reasons for its lack of success in some patients remain unknown. The aim of this study was to try to identify a new predictor of AF recurrence following catheter-based treatment. This prospective study enrolled a cohort of patients with AF. Based on the results of a one-year follow-up, patients were divided into two groups: Group 1 (“vein-dependent” AF)—patients who achieved a successful outcome after 1–2 catheter ablation procedures—and Group 2 (“non-vein-dependent” AF)—patients with confirmed complete pulmonary vein isolation (PVI) or with an identified “non-vein-dependent” AF substrate. Blood samples were collected prior to the procedure and biobanked. Initial proteomic profiling of the serum using protein microarrays identified several candidate proteins, whose elevated levels were subsequently confirmed by an enzyme-linked immunosorbent assay (ELISA). This article presents data on one such protein—TAG72. A comparison of TAG72 levels (%OD normalized units) between Group 1 (“vein-dependent” AF) and Group 2 (“non-vein-dependent” AF) revealed a statistically significant increase in the latter group (128.9 98.2; 284.4 vs. 84.3 73.8; 92.1, p < 0.001). These data provide the first evidence implicating TAG72 in the pathogenesis of AF.

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