What does this research mean for the field?

Both high triglyceride-glucose index and high visceral adiposity are independently associated with arterial stiffness. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This research investigates the combined effects of triglyceride-glucose index and visceral adiposity on arterial stiffness.

January 10, 2026Artery Research0 citationsOpen Access

The Interaction Between Triglyceride–Glucose Index and Visceral Adiposity in Arterial Stiffness

GWGuoyu WangNantong University CZC. ZHANGNantong University SJSuyun JiangNantong University

Key Result

Both high triglyceride-glucose index and high visceral adiposity were independently associated with arterial stiffness (OR, 3.786 and OR, 4.689 respectively, p < 0.001).

Key Points

This research investigates the combined effects of triglyceride-glucose index and visceral adiposity on arterial stiffness.
761 participants underwent health examinations measuring blood glucose, lipid profiles, visceral fat area, and arterial stiffness.
Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV).
Logistic regression and interaction analyses were applied to evaluate the effects of triglyceride-glucose index and visceral adiposity.
High triglyceride-glucose index and visceral adiposity independently correlated with increased arterial stiffness.
A significant interaction effect between the triglyceride-glucose index and visceral adiposity was observed.
Quantitative measures indicated a robust combined risk associated with these factors on vascular health.

Structured PICO

Does the interaction between the Triglyceride-Glucose (TyG) index and visceral adiposity affect arterial stiffness in adults?

Population

761 adults (age ≥ 35 years, currently employed hospital staff), mean age 44.50 ± 7.40 years, 75.95% female, undergoing health examinations at a tertiary hospital in China.

Intervention

High Triglyceride-Glucose (TyG) index (≥9.079) and high visceral fat area (VFA ≥80 cm²)

Comparator

Low TyG index (<9.079) and low visceral fat area (VFA <80 cm²)

Outcome

Arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV ≥ 1400 cm/s)surrogate

The TyG index and visceral fat area have an independent and interactive antagonistic effect on arterial stiffness, highlighting the importance of considering both markers in cardiovascular risk assessment.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Abstract Background Arterial stiffness is a critical determinant of cardiovascular risk and is influenced by various metabolic factors. The triglyceride-glucose (TyG) index, an emerging marker of insulin resistance, and visceral adiposity are both associated with arterial stiffness. However, the interaction between TyG index and visceral adiposity in relation to arterial stiffness has not been thoroughly explored. Methods A total of 761 participants underwent health examinations, including measurements of fasting blood glucose, lipid profiles, visceral fat area (VFA), and arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV). Participants were stratified by TyG index and VFA. Logistics regression and interaction analyses were conducted to assess the combined effect of TyG and VFA on arterial stiffness. Results Both the high TyG index and high VFA were independently associated with arterial stiffness(OR, 3.786, 95% CI 2.383, 6.014, p <0.001; OR, 4.689, 95% CI 2.770, 7.940, p <0.001, respectively). A significant interaction between TyG index and VFA on arterial stiffness was found (p for interaction <0.001), with a relative excess risk due to interaction (RERI) of -10.410 (95% CI -11.746, -9.074), an attributable proportion due to interaction (AP) of -1.474 (95% CI -1.644,-1.284), and an synergy index (SI) of 0.118 (95% CI 0.105, 0.131). Conclusions The TyG index interacts with VFA on arterial stiffness. This interaction highlights the importance of considering both markers in risk assessment of arterial stiffness and prevention strategies aimed at improving vascular health.

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