January 10, 2026Zeitschrift für Medizinische Physik0 citationsOpen Access

Development and application of a structured preclinical protocol for MRI-guided endomyocardial biopsy: a multimodal imaging approach using a hybrid vessel phantom and porcine in vivo models

DBDenis Gholami BajestaniComprehensive Cancer Center Mainfranken CRC. Martin ReichLeipzig University JBJan BirkigtLeipzig University

Key Result

The MRI-guided endomyocardial biopsy protocol demonstrated reliable visibility and accurate tissue sampling of MR-compatible EMB forceps in preclinical tests.

Key Points

To develop and apply a structured preclinical protocol for MRI-guided endomyocardial biopsy using multimodal imaging.
Developed a hybrid vessel phantom for testing
Utilized porcine in vivo models for evaluation
Assessed visibility, handling, and tissue sampling accuracy of MR-compatible EMB forceps
Demonstrated reliable visibility of the biopsy device
Ensured effective handling during procedures
Achieved accurate tissue sampling results

Structured PICO

Does a structured preclinical protocol effectively evaluate the characteristics of MR-compatible endomyocardial biopsy forceps in phantom and porcine models?

Population

Hybrid vessel phantom and porcine in vivo models

Intervention

MRI-guided endomyocardial biopsy using MR-compatible EMB forceps

Outcome

Device characteristics (reliable visibility, handling, and accurate tissue sampling)

A structured preclinical protocol using phantom and porcine models successfully evaluated the visibility, handling, and sampling accuracy of MR-compatible endomyocardial biopsy forceps.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

The developed preclinical testing protocol effectively evaluated key device characteristics (reliable visibility, handling, and accurate tissue sampling) of the MR-compatible EMB forceps, providing valuable insights in the early stages of in vivo trials.

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