Key result
Arterial spin labeling MRI detects corpus callosum hyperperfusion in a successfully treated Marchiafava-Bignami disease case.
Why the study?
Previous studies in Marchiafava-Bignami disease mostly found hypoperfusion of the corpus callosum and extra-callosal lesions, whereas hyperperfusion of the corpus callosum has rarely been described.
This case report highlights a rare presentation of Marchiafava-Bignami disease with hyperperfusion in the corpus callosum on arterial spin labeling MRI, followed by complete recovery.
Answers are grounded in this paper and cite their sources.
May signal inflammatory hyperperfusion variant in Marchiafava–Bignami disease; challenges prior hypoperfusion reports but leaves open clinical relevance.
Marchiafava–Bignami disease (MBD) is a rare demyelinating disease, which mostly diagnosed among alcoholics. Previous studies on cerebral perfusion of patients with MBD mostly found hypoperfusion of corpus callosum and extra-callosal lesions. Nevertheless, hyperperfusion of corpus callosum in MBD has rarely been described.The aim of this study was to report a case of MBD with hyperperfusion on arterial spin labeling and completely recovered. We described a case of MBD with hyperperfusion in the corpus callosum on arterial spin labeling perfusion magnetic resonance imaging, presented with altered mental state. This MBD patient eventually achieved a complete recovery. We suppose that the hyperperfusion of corpus callosum in this patient may be associated with the vasodilation caused by the inflammatory response in the lesions. Future researches are needed to confirm our finding.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2026) studied this question. A case of Marchiafava–Bignami disease presented with hyperperfusion in the corpus callosum and achieved complete recovery after treatment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: