Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review

Figures

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  FIGURE 1. Axial images of brain MRI performed 7 days (A–C) and 22 days (D) after onset. MRI performed 7 days after onset revealed symmetrical and bilateral hyperintense lesions on diffusion-weighted imaging (DWI) (A), and T2-weighted imaging (B) throughout the entire corpus callosum (CC). Extracallosal lesions could also be seen (A,B). T2-weighted imaging had a considerable amount of distortion due to motion because the patient couldn’t cooperate well (B). Gadolinium enhancement could be seen in part of splenium (C, arrow). 22 days after onset, follow-up MRI showed only mild remaining of the formerly impressively hyperintensity on D2-weighted imaging, and the formation of necrosis in the splenium (D).

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  FIGURE 2. Sagittal images of brain MRI performed 7 days (A,B) and 22 days (C) after onset. MRI performed 7 days after onset revealed hyperintense lesions on T2-weighted imaging throughout the entire CC and in some extracallosal regions (A). Lesions that were enhanced by gadolinium could be seen in the splenium (arrow) and some extracallosal regions (B). Follow-up head MRI performed 22 days after onset showed necrosis without enhancement had occurred in the formerly gadolinium-enhanced lesions (C).