Initially Normal MRI , Delayed Splenial Lesion in Marchiafava‐Bignami Disease

Tsuyoshi Nojima; Ryo Tanabe; Takafumi Obara; T Hongo; Atsuyoshi Iida

doi:10.1002/ccr3.71926

January 22, 2026Clinical Case ReportsOpen Access

Initially Normal MRI , Delayed Splenial Lesion in Marchiafava‐Bignami Disease

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Key Points

The study aims to highlight the occurrence of splenial lesions in Marchiafava-Bignami disease despite initial normal MRI findings.
Observational analysis of MRI findings in patients with a history of alcohol use disorder or thiamine deficiency.
Assessment of imaging results over time to identify development of splenial lesions.
Initial MRIs may appear normal in patients, but splenial lesions can develop later.
Emphasizing repeat imaging, especially for at-risk patients, can help in timely diagnosis.

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Implication

Observational study highlights the importance of repeat MRI to identify splenial lesions in patients at risk of Marchiafava-Bignami disease, suggesting timely recognition is critical.

Abstract

Marchiafava–Bignami disease (MBD) may show normal findings on early MRI. In patients with alcohol use disorder or risk of thiamine deficiency, repeat imaging is important because splenial lesions can develop later. Recognizing this pattern is key to avoiding delayed diagnosis.

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Cite This Study

Nojima et al. (2026) studied this question.

synapsesocial.com/papers/6975b2aefeba4585c2d6e2a3 https://doi.org/10.1002/ccr3.71926

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Initially Normal MRI , Delayed Splenial Lesion in Marchiafava‐Bignami Disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Initially Normal MRI , Delayed Splenial Lesion in Marchiafava‐Bignami Disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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