What question did this study set out to answer?

To evaluate the long-term clinical outcomes associated with non-culprit plaque rupture in STEMI patients.

January 10, 2026EuroIntervention1 citationsOpen Access

Long-term clinical outcomes of non-culprit plaque rupture in STEMI

JZJiawei ZhaoHarbin Medical University RZRui ZhaoHarbin Engineering University YCYuzhu ChenHarbin Engineering University

Key Result

Non-culprit plaque rupture in STEMI patients is linked to poor long-term outcomes primarily due to non-ruptured Thin-Cap Fibroatheromas (TCFA) indicating higher risk events.

Key Points

To evaluate the long-term clinical outcomes associated with non-culprit plaque rupture in STEMI patients.
Analyzed clinical outcomes in patients with non-culprit plaque ruptures.
Assessed the impact of non-ruptured TCFA on prognosis.
Monitored subsequent cardiovascular events over a long-term period.
Patients with non-culprit plaque rupture showed a poor long-term prognosis.
Non-ruptured TCFA identified high-risk lesions for future cardiac events.

Structured PICO

Does the presence of non-ruptured TCFA identify lesions at increased risk of subsequent events in STEMI patients with non-culprit plaque rupture?

Population

Patients with STEMI and non-culprit plaque rupture

Intervention

Presence of non-ruptured TCFA (thin-cap fibroatheroma)

Outcome

Long-term prognosis and subsequent events

In STEMI patients, non-ruptured thin-cap fibroatheroma (TCFA) is the primary driver of poor long-term prognosis and subsequent events, rather than non-culprit plaque rupture itself.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Patients with non-culprit plaque rupture had a poor long-term prognosis, which is predominantly due to the effect of non-ruptured TCFA. Non-ruptured TCFA, not plaque rupture, can identify lesions at increased risk of subsequent events.

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