What question did this study set out to answer?

The aim is to assess cardiovascular risks and interventions relevant to breast cancer survivors.

January 10, 2026Cardio-Oncology0 citationsOpen Access

Heart failure related cardiotoxicity in breast cancer survivors: a scoping review

PVPinyadapat VacharanukrauhFederation University KMKyle J. MillerAustralian Regenerative Medicine Institute SASheikh Mohammad AlifKhulna University

Key Result

Breast cancer survivors have a significant risk of heart failure and all-cause mortality, highlighting the need for early cardiovascular risk assessment and targeted interventions.

Key Points

The aim is to assess cardiovascular risks and interventions relevant to breast cancer survivors.
Conducted a scoping review of existing literature on heart failure and cardiotoxicity in breast cancer survivors.
Evaluated the need for cardiovascular risk assessment and surveillance strategies.
Identified gaps in current research related to targeted cardioprotective interventions.
Breast cancer survivors experience significant heart failure risks and cardiovascular disease mortality.
Early assessments of cardiovascular risk can improve long-term health outcomes.
Emphasizing the necessity for tailored interventions and ongoing monitoring to mitigate risks.

Structured PICO

Does breast cancer and its associated treatments increase the risk of incident heart failure and mortality compared to healthy non-cancer controls?

Population

15 population-based cohort studies including individuals diagnosed with breast cancer (mostly early-stage I-III), with sample sizes ranging from 294 to 122,217.

Intervention

Breast cancer diagnosis and associated treatments (including chemotherapy, radiotherapy, surgery, and targeted therapies such as anthracyclines or trastuzumab).

Comparator

Healthy (non-breast cancer) control groups.

Outcome

Incidence of heart failure, cardiovascular mortality, and all-cause mortality.hard clinical

Breast cancer survivors face a substantial and sustained risk of heart failure and all-cause mortality, highlighting the critical need for early cardiovascular risk assessment and long-term surveillance.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Breast cancer survivors face a substantial and sustained cardiovascular burden, particularly for HF and all-cause mortality. These findings emphasise the need for early CVD risk assessment, targeted cardioprotective interventions, and long-term surveillance. Large, prospective studies are essential to inform precision cardio-oncology and optimise survivorship outcomes.

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