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January 10, 2026Journal of Mechanics in Medicine and Biology

Biotechnology and Bioengineering Innovations in Precision Obesity Management: Mechanistic Insights, Emerging Platforms, and Translational Pathways

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Key result

Precision biotechnology and bioengineering innovations can enhance personalized obesity management via multi-omics and synthetic biology.

Why the study?

Conventional obesity interventions remain limited by poor durability, safety concerns, and scalability, underscoring the need for precision alternatives that target upstream regulatory nodes.

Design

Review

Authors

MHMin Ho HanYHYoun Seon HwangDJDo Hyeon Jin

Discussion

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Overview

May inform obesity research directions; leaves open clinical translation pending prospective validation.

Key Points

  • This review aims to explore how biotechnology and bioengineering can revolutionize obesity management through precision approaches.
  • Discusses the systemic nature of obesity and the role of impaired signaling pathways.
  • Explores the use of multi-omics for patient stratification and biomarker prediction.
  • Outlines emerging technologies like synthetic biology and engineered microbiomes for metabolic intervention.
  • Evaluates precision delivery systems for targeted treatment.
  • Highlights the limitations of traditional obesity interventions.
  • Describes how advances in biotechnology redefine obesity and require a patient-centered approach.
  • Identifies challenges such as immune clearance and regulatory harmonization.

Cite This Study

Han et al. (2025) studied this question. Precision biotechnology and bioengineering innovations, such as multi-omics and synthetic biology, can significantly enhance personalized obesity management strategies.

synapsesocial.com/papers/6963221691e05aa366cb8912https://doi.org/10.1142/s0219519426300012
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity: Genetic Insights, Therapeutic Strategies, Pharmacoeconomic Impact, and Psychosocial Dimensions2025 · 2 citations
  2. 2Restructuring the Obesity Paradigm: Molecular Etiologies, Clinical Complexities, and the Future of Precision Intervention2026
  3. 3ARTIFICIAL INTELLIGENCE AND PRECISION MEDICINE IN OBESITY MANAGEMENT: CURRENT APPLICATIONS, CHALLENGES, AND FUTURE DIRECTIONS2026
  4. 4Integrating Precision Medicine and Digital Health in Personalized Weight Management: The Central Role of Nutrition2025 · 26 citations
  5. 5Biomaterial‐Driven Therapeutic Strategies for the Integrated Management of Obesity2026