What question did this study set out to answer?

Synthesize current evidence from single- and multi-omics investigations to identify emerging biomarkers, molecular subtypes, and translational barriers in precision obesity care.

October 24, 2025Molecular Omics

The omics revolution in obesity: from molecularsignatures to clinical solutions

View Full Paper

Ask AI

Bookmark

Authors

MMMohammad MustafaMinistry of Defence AAAmr A. ArafatMinistry of Defence WAWaleed AlhazzaniMinistry of Defence

Discussion

Member takes

Implication

Review reveals molecular multiomics signatures in obesity phenotypes, highlighting novel targets for personalized clinical interventions.

Key Points

Synthesize current evidence from single- and multi-omics investigations to identify emerging biomarkers, molecular subtypes, and translational barriers in precision obesity care.
Review and synthesis of genomics, epigenomics, transcriptomics, proteomics, and metabolomics evidence in obesity pathophysiology.
Evaluation of artificial intelligence frameworks and multi-omics data integration for patient stratification, risk modeling, and therapeutic guidance.
Genomic loci, polygenic risk scores, and DNA methylation markers at CPT1A and HIF3A delineate distinct, modifiable biological pathways in metabolic dysfunction.
Metabolomic profiling identifies ceramide-driven and branched-chain amino acid-dominant subtypes capable of directing targeted therapies such as SGLT2 inhibitors and GLP-1 agonists.
Clinical implementation remains restricted to research settings due to insufficient cohort diversity, unharmonized datasets, and absent standardized validation protocols.

Cite This Study

Mustafa et al. (2025) studied this question.

synapsesocial.com/papers/6a8b8e4af71b672e3df481e9 https://doi.org/10.1039/d5mo00074b

View Full Paper

Ask AI

Bookmark

The omics revolution in obesity: from molecularsignatures to clinical solutions

Discussion

Member takes

Implication

Key Points

Cite This Study

The omics revolution in obesity: from molecularsignatures to clinical solutions

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider