Increased expression of Tie2 (100% vs. 33.3%) and Angiopoietin 2 (100% vs. 50%) was found in the endothelial cells of rosacea skin compared to non-lesional skin.
Rosacea lesions show increased expression of Tie2 and Angiopoietin 2 compared to non-lesional skin, suggesting a role in the disease's vascular changes.
Absolute Event Rate: 0% vs 0%
In this study we evaluated the expression of Angiopoietin 1, Angiopoietin 2, and Tie2 by immunohistochemistry in the skin of 10 patients with erythemato telangiectatic and papulopustular rosacea. Significantly increased expression of Tie2 and Angiopoietin 2 in the endothelial cells of the dermal vessels in rosacea skin vs. non-lesional skin (100% and 33.3% for Tie2, and 100% and 50% for Angiopoietin 2) was observed. There was no difference in the expression of Angiopoietin 1 and phosphorylated Tie2 (pTie2) between the lesional skin of rosacea and non-lesional skin.
Kaya et al. (Thu,) reported a other. Increased expression of Tie2 (100% vs. 33.3%) and Angiopoietin 2 (100% vs. 50%) was found in the endothelial cells of rosacea skin compared to non-lesional skin.