What question did this study set out to answer?

This research aims to investigate the relationship between preoperative prealbumin levels and postoperative complications in elderly colorectal cancer patients.

January 10, 2026Nihon Daicho Komonbyo Gakkai Zasshi0 citationsOpen Access

Association between Preoperative Prealbumin Level and Postoperative Complications in Elderly Patients with Colorectal Cancer

Q: What does this research mean for the field?

Preoperative prealbumin levels are associated with postoperative complications, and a greater than 10% increase in levels is linked to reduced complication rates in elderly colorectal cancer patients. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

MKMasatoshi KitakazeOsaka International Cancer Institute MPMasakatsu PakuThe University of Texas MD Anderson Cancer Center SSSatoshi SugimotoTeikyo Heisei University

Key Result

Preoperative prealbumin levels were associated with postoperative complications, with a greater than 10% increase in levels linked to reduced complication rates in elderly colorectal cancer patients.

Key Points

This research aims to investigate the relationship between preoperative prealbumin levels and postoperative complications in elderly colorectal cancer patients.
Examined 29 colorectal cancer patients aged over 80 undergoing surgery from June 2018 to March 2023.
Investigated the correlation between preoperative prealbumin levels and postoperative complications.
Performed nutritional interventions for patients with prealbumin levels ≤15 mg/dL and analyzed outcomes.
Age and prealbumin levels were identified as independent risk factors for postoperative complications (P<0.05 and P<0.01, respectively).
Nutritional intervention led to a greater than 10% increase in prealbumin levels, correlating with reduced incidence of postoperative complications and decreased severity.

Structured PICO

Does preoperative nutritional intervention to improve prealbumin levels reduce postoperative complications in elderly patients with colorectal cancer?

Population

29 colorectal cancer patients aged 80 years or older (median age 84, 17 males) who underwent primary resection between June 2018 and March 2023.

Intervention

Nutritional intervention for approximately 2 weeks in patients with initial prealbumin ≤15 mg/dL (n=10), including central venous nutrition and elemental diet, with or without bowel obstruction relief.

Comparator

Patients without nutritional intervention, or comparing patients who achieved a >10% increase in prealbumin versus those who did not.

Outcome

Postoperative complications assessed by the Clavien-Dindo classification.safety

Preoperative prealbumin level is an independent risk factor for postoperative complications in elderly colorectal cancer patients, and targeted nutritional intervention may help reduce this risk.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

目的：高齢者における大腸癌の術後合併症と術前プレアルブミン値との関連を明らかにし，術前プレアルブミン値の改善と効果を評価する．方法：2018年6月から2023年3月に原発巣切除を受けた80歳以上の大腸癌患者29例を対象とし，術前プレアルブミン値と術後合併症との関係を検討した．また，術前プレアルブミン値が15mg/dL以下の患者に対して栄養介入を実施した症例でのプレアルブミン値の推移，合併症との関係を検討した．結果：年齢（P＜0.05）とプレアルブミン値（P＜0.01）が独立した術後合併症のリスク因子であった．栄養介入によりプレアルブミン値が10％以上上昇した症例では，その他の低プレアルブミン値の患者に比べて術後合併症の発生率が低下し，重症度も軽減される傾向を認めた．結論：術前プレアルブミン値が大腸癌患者の術後合併症リスクと関連し，プレアルブミン値を上昇させることで術後合併症リスクを低減できる可能性が示唆された．

Ask AI

Helpful

Bookmark

View Full Paper