Data mining based on multiomic data integration to explore the mechanism by which a proprietary Chinese medicine improves cardiac hypertrophy in heart failure.

Key Result

XYT improved heart failure by inhibiting HDAC2 and suppressing AKT/GSK-3β signaling, reducing oxidative stress, hypertrophy, and fibrosis.

Key Points

• The aim is to investigate the mechanism by which a proprietary Chinese medicine improves cardiac hypertrophy in heart failure.
• Utilized data mining techniques for analyzing multiomic data integration.
• Focused on the role of HDAC2 in cardiac hypertrophy.
• Examined the impact on oxidative stress and fibrosis.
• The proprietary medicine, XYT, targets HDAC2 to suppress AKT/GSK-3β signaling.
• Improvement in cardiac hypertrophy and reduction of oxidative stress.
• Mitigation of fibrosis was also observed, supporting the clinical relevance.