What does this research mean for the field?

The rs1812266 locus is associated with a reduced risk of arterial hypertension (OR = 0.74; p = 0.028) in patients with uterine fibroids. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

To determine whether genetic loci associated with uterine fibroids in genome-wide association studies also contribute to arterial hypertension susceptibility.

January 10, 2026Frontiers in Bioscience-ScholarOpen Access

Uterine Fibroids-Associated GWAS Loci and the Risk of Arterial Hypertension: A Pilot Study

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Key result

The rs1812266 locus is linked to ~26% lower arterial hypertension risk in uterine fibroid patients.

p = 0.028

Why the study?

Increasing epidemiological evidence demonstrates a bidirectional relationship between uterine fibroids and arterial hypertension, but the underlying genetic mechanisms remain unclear.

Do uterine fibroids-associated GWAS loci contribute to arterial hypertension susceptibility in women with uterine fibroids?

Population

606 hospitalized patients with uterine fibroids (178 with comorbid AH, 428 AH-free)

Comparison

Comorbid AH vs AH-free

Design

Pilot genetic association study

Authors

LPLiubov null PonomarevaKursk State Medical University ADAnna null DorofeevaKursk State Medical University JSJulia null SamoylenkoKursk State Medical University

Discussion

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Implication

May inform risk stratification in fibroid patients; hypothesis-generating for shared loci and requires prospective validation.

Key Points

To determine whether genetic loci associated with uterine fibroids in genome-wide association studies also contribute to arterial hypertension susceptibility.
Analyzed genomic DNA from 606 hospitalized women with ultrasound-verified uterine fibroids (178 with comorbid arterial hypertension and 428 normotensive controls) in Central Russia.
Genotyped 17 common genome-wide association study-derived polymorphisms using allele-specific PCR amplification.
Assessed gene–gene and gene–environment interactions using model-based multivariate dimensionality reduction analysis combined with functional bioinformatics annotation.
The rs1812266 polymorphism (LOC105375949) was associated with a reduced risk of arterial hypertension (OR = 0.74; p = 0.028).
Model-based multivariate dimensionality reduction identified significant gene–gene interactions (pperm ≤ 0.05), with variants rs66998222, rs2456181, rs1812266, rs10929757, and rs7986407 appearing across multiple risk models.
Gene–environment analysis revealed five variants interacting with lifestyle risk factors, centered on a smoking by rs66998222 interaction across five separate models.

Structured PICO

Do uterine fibroids-associated GWAS loci contribute to arterial hypertension susceptibility in women with uterine fibroids?

Population

606 hospitalized women with uterine fibroids (n=178 with comorbid arterial hypertension; n=428 AH-free) from Central Russia with self-declared Russian ancestry.

Intervention

Genotyping of 17 common GWAS-derived polymorphisms associated with uterine fibroids.

Comparator

Normotensive controls (AH-free patients with uterine fibroids).

Outcome

Risk of arterial hypertension (AH susceptibility).surrogate

This study provides novel molecular evidence for shared pathophysiological pathways between uterine fibroids and arterial hypertension, highlighting specific genetic variants and gene-environment interactions.

Cite This Study

Ponomareva et al. (2025) studied this question. The rs1812266 locus was associated with a reduced risk of arterial hypertension (OR = 0.74; p = 0.028) in patients with uterine fibroids.

synapsesocial.com/papers/6963224191e05aa366cb8db0 https://doi.org/10.31083/fbs42728

Topics

Hypertension management Pulmonary embolism Semaglutide

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Uterine Fibroids-Associated GWAS Loci and the Risk of Arterial Hypertension: A Pilot Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Uterine Fibroids-Associated GWAS Loci and the Risk of Arterial Hypertension: A Pilot Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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