August 31, 2013AJP Heart and Circulatory Physiology
Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis
Key result
The TAPSE/PASP ratio <0.36 mm/mmHg predicts a 10.4-fold increase in risk of adverse events in heart failure patients compared to higher ratios.
Why the study?
Does the TAPSE-to-PASP ratio predict prognosis in patients with heart failure?
Population
Heart failure patients with reduced (HFrEF) or preserved (HFpEF) left ventricular ejection fraction
Design
Cohort
Follow-up
median 20.8 months
Authors
Discussion
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Implication
The TAPSE/PASP ratio is a powerful, non-invasive prognostic indicator of right ventricular function and survival in heart failure patients, regardless of whether they have HFrEF or HFpEF.
Key Points
- To investigate the relationship between TAPSE and PASP in heart failure and its prognostic implications.
- Conducted echo-Doppler studies on 293 heart failure patients (HFrEF and HFpEF)
- Measured TAPSE and PASP to assess right ventricular contractile function
- Performed Cox regression and Kaplan-Meier analyses to evaluate prognosis based on TAPSE and PASP
- Tracked adverse events over a median follow-up of 20.8 months
- Nonsurvivors exhibited a downward shift in TAPSE vs. PASP relationship
- Patients with lower TAPSE and higher PASP had worse outcomes
- TAPSE/PASP ratio provided better prognostic resolution
- Hazard ratios indicated significant risks associated with TAPSE and PASP levels
Structured PICO
Does the TAPSE-to-PASP ratio predict prognosis in patients with heart failure?
P
Population
Heart failure patients with reduced (HFrEF) or preserved (HFpEF) left ventricular ejection fraction
I
Intervention
Echocardiographic assessment of TAPSE-to-PASP ratio (TAPSE/PASP)
O
Outcome
Adverse events (survival/mortality)hard clinical
The TAPSE/PASP ratio is a powerful, non-invasive prognostic indicator of right ventricular function and survival in heart failure patients, regardless of whether they have HFrEF or HFpEF.
Cite This Study
Guazzi et al. (2013) studied this question. The TAPSE/PASP ratio <0.36 mm/mmHg predicts a 10.4-fold increase in risk of adverse events in heart failure patients compared to higher ratios.