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January 14, 2026Open Forum Infectious Diseases0 citationsOpen Access

Efficacy of Helicobacter pylori Eradication with Saccharomyces boulardii in Meta-Analysis

P-157. Efficacy and Safety of Helicobacter pylori Triple Therapy With and Without Saccharomyces boulardii Supplementation: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Authors

OEOmar ElkoumiAEAhmed ElkoumiMEMariam Khaled Elbairy

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Overview

Meta-analysis demonstrates Saccharomyces boulardii improves H. pylori eradication and reduces adverse events.

Key Points

  • This research aims to evaluate the efficacy and safety of Saccharomyces boulardii in H. pylori treatment.
  • Conducted a systematic search in major databases
  • Included randomized controlled trials comparing triple therapy with and without S. boulardii
  • Utilized statistical analyses including Mantel–Haenszel method
  • Higher H. pylori eradication rates (RR 1.13; p < 0.00001) in patients with S. boulardii
  • Reduced incidence of vomiting (RR 0.24; p = 0.05)
  • Lower diarrhea rates (RR 0.40; p < 0.00001)
  • Decreased taste distortion (RR 0.72; p = 0.01)
  • Reduced abdominal distension (RR 0.67; p = 0.02) and abdominal pain (RR 0.53; p = 0.002)

Cite This Study

Elkoumi et al. (2026) studied this question.

synapsesocial.com/papers/6966f33213bf7a6f02c01158https://doi.org/10.1093/ofid/ofaf695.381
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