Oxyprenyl-Chalcones as Antibacterial Hits: Design of Experiments-Optimized Synthesis, Antibacterial Evaluation, Early Drug-Like Profiling and Biodegradability Prediction

Key Points

• The aim is to develop and evaluate novel oxyprenyl-chalcones as potential antibiotics against antimicrobial resistance.
• Conducted a design of experiments to optimize the synthesis of oxyprenyl-chalcones.
• Evaluated the antibacterial activity of synthesized chalcones against various bacterial strains.
• Performed early drug-like profiling to assess potential as pharmaceuticals.
• Predicted biodegradability of compounds to evaluate environmental impact.
• Identified several oxyprenyl-chalcones with significant antibacterial activity.
• Some compounds demonstrated broad spectrum efficacy against multiple bacterial strains.
• Biodegradability predictions suggested environmentally friendly profiles for selected chalcones.