All obese individuals are not created equal: insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals
Key result
Insulin resistance, rather than degree of adiposity, is the primary determinant of cardiovascular disease risk in overweight/obese individuals.
Structured PICO
P
Population
Overweight and obese individuals
O
Outcome
Cardiovascular disease risk and insulin resistance
Insulin resistance is the primary driver of cardiovascular risk in obesity, and simple BMI is as effective as waist circumference or visceral fat imaging in predicting insulin resistance.
Authors
Discussion
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Implication
May support IR-focused risk assessment over adiposity alone in obesity; leaves open causal validation in prospective trials.
Cite This Study
Gerald M. Reaven (2005) studied this question. Insulin resistance, rather than degree of adiposity, is the primary determinant of cardiovascular disease risk in overweight/obese individuals.