AbstractThe convergence of traditional Indian Knowledge Systems (IKS) with modern biological data analysis offers a groundbreaking direction in contemporary biosciences. This paper investigates the potential of integrating ancient Indian wisdom such as Ayurveda, herbal remedies, and indigenous ecological practices with advanced computational approaches including artificial intelligence (AI), data analytics, and bioinformatics. It outlines a multidisciplinary model for reinterpreting traditional insights using digital tools, enabling scientific validation, scalability, and practical implementation. Computational platforms like R, Python, BLAST, and machine learning algorithms play a crucial role in digitizing and analyzing this knowledge, while also advancing predictive modeling and systems biology. This synthesis opens new avenues in drug discovery, personalized healthcare, sustainable farming, and environmental protection. By mapping phytochemical profiles to molecular targets, researchers can identify bioactive compounds with therapeutic relevance. Traditional taxonomies and usage patterns can be translated into structured databases, offering repositories for future ethnopharmacological research. The integration further supports the development of interoperable tools for hypothesis generation, adverse effect prediction, and precision treatment strategies. Moreover, blending ancient knowledge with high-throughput technologies strengthens community-based healthcare and biodiversity conservation. This fusion represents not merely a revival of tradition but a forward-looking strategy to solve pressing global health and ecological challenges through scientific innovation.
Chauhan et al. (2025) studied this question.