Key result
Diabetes linked to ~66% fewer acute coronary thrombi vs controls despite greater plaque burden.
Effect estimate: OR 0.34 (95% CI 0.21-0.54)
p-value: p=0.001
Diabetes mellitus drives a distinct, more active atherogenic process characterized by increased plaque burden, larger necrotic cores, and extensive vascular calcification.
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Reduced acute thrombi in diabetic coronary lesions despite greater burden may reflect distinct plaque biology; leaves open calcification's role in event rates.
Yahagi et al. (2016) conducted a review in Diabetes Mellitus. Coronary lesions from subjects with type 1 diabetes mellitus and type 2 diabetes mellitus exhibited lower incidence of acute thrombi (OR 0.34, 95% CI 0.21-0.54, P=0.001) compared to nondiabetic controls despite greater plaque burden.
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