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The research aims to develop a method for assessing the structural integrity of DNA origami in vivo to enhance therapeutic applications.

January 18, 2026Nature NanotechnologyOpen Access

Resolving DNA origami structural integrity and pharmacokinetics in vivo

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The research aims to develop a method for assessing the structural integrity of DNA origami in vivo to enhance therapeutic applications.
Introduced proximity ligation assay for structural tracking and integrity quantification (PLASTIQ) using blood samples.
Measured degradation of DNA origami structures longitudinally in a murine model.
Evaluated the effectiveness of PEGylation in slowing degradation of DNA origami.
Achieved structural integrity quantification with a detection limit of 0.01 fM using only 1 µl of blood.
Identified distinct degradation kinetics of DNA helices based on location within the origami structure.
Observed slower degradation rates for internal helices compared to outer helices.

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Demonstrates a novel assay for evaluating DNA origami integrity in vivo, suggesting its potential for therapeutic applications.

Wang et al. (2026) studied this question.

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