Key result
The instantaneous wave-free ratio is a drug-free index of stenosis severity comparable to fractional flow reserve (FFR).
Why the study?
Does the instantaneous wave-free ratio provide a drug-free index of stenosis severity comparable to FFR?
Does the instantaneous wave-free ratio provide a drug-free index of stenosis severity comparable to FFR?
The instantaneous wave-free ratio offers a novel, adenosine-independent method to assess coronary stenosis severity that is comparable to FFR.
Offers preliminary support for adenosine-free stenosis assessment; leaves open randomized outcome trials before practice change.
Intracoronary resistance is naturally constant and minimized during the wave-free period. The instantaneous wave-free ratio calculated over this period produces a drug-free index of stenosis severity comparable to FFR. (Vasodilator Free Measure of Fractional Flow Reserve [ADVISE]; NCT01118481).
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Sen et al. (2011) studied this question. The instantaneous wave-free ratio is a drug-free index of stenosis severity comparable to fractional flow reserve (FFR).
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