What does this research mean for the field?

The instantaneous wave-free ratio is a drug-free index of stenosis severity comparable to fractional flow reserve (FFR). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

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December 10, 2011Open Access

Development and Validation of a New Adenosine-Independent Index of Stenosis Severity From Coronary Wave–Intensity Analysis

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Key Result

The instantaneous wave-free ratio is a drug-free index of stenosis severity comparable to fractional flow reserve (FFR).

Structured PICO

Does the instantaneous wave-free ratio provide a drug-free index of stenosis severity comparable to FFR?

Intervention

Instantaneous wave-free ratio (iFR)

Comparator

Fractional Flow Reserve (FFR)

Outcome

Comparability of the drug-free index of stenosis severity to FFRsurrogate

The instantaneous wave-free ratio offers a novel, adenosine-independent method to assess coronary stenosis severity that is comparable to FFR.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Intracoronary resistance is naturally constant and minimized during the wave-free period. The instantaneous wave-free ratio calculated over this period produces a drug-free index of stenosis severity comparable to FFR. (Vasodilator Free Measure of Fractional Flow Reserve ADVISE; NCT01118481).

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Discussion

Authors

Sayan Sen

Interventional Cardiology

Javier Escaned

Interventional Cardiology

Iqbal Malik

Structural Heart Disease

Journals

Journal of the American College of Cardiology

Actions

Institutions

Imperial College London

Hammersmith Hospital

Lung Institute

References and Citations

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Discussion

Cite this study

Sen et al. (Sat,) reported a other. The instantaneous wave-free ratio is a drug-free index of stenosis severity comparable to fractional flow reserve (FFR).

synapsesocial.com/papers/6970ddc7da50910f9664e714 — DOI: https://doi.org/10.1016/j.jacc.2011.11.003

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Physiological Basis of Clinically Used Coronary Hemodynamic Indices· 2006 · 254 citations
Our Preoccupation With Coronary Luminology· 1995 · 1,102 citations

Development and Validation of a New Adenosine-Independent Index of Stenosis Severity From Coronary Wave–Intensity Analysis

Key Result

Structured PICO

Main Result

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider